Everyone is different, and some of us have different, more responsive ESCes, and it also may impact how we are able to possibly metabolize THC. But if you’re curious as to why your tolerance is like this, it’s important to find out. This can be both an advantage and a disadvantage. Sure it’s cheaper, but the side effects can be much greater in those who have much lower side effects.
Newbies to Cannabis
Usually, those who are new to it do not have a tolerance, so they’re going to experience more effects. If you use it more and more, this builds up over time, reducing chances of reacting in a bad way to cannabis.
The Gender Difference
Women tend to be much more sensitive to THC, and this also can impact how they respond based on the menstrual cycle. THC does benefit women because of the analgesic uses. However, because of their less tolerance, they tend to have more anxiety because they use too much.
Men also create less 11-OH-THC, which is basically the THC that's made after edibles come in. That's why women can feel a lot more sensitivity when they have edibles infused with this. The fat distribution and the hormones also play a part in this too. It also is worth noting that in some studies, there were few differences in the THC metabolisms that rats both male and female, had in their bodies. So there may be different effects when you’re looking specifically at the difference in these effects for both.
Different Endocannabinoid Tone
This is basically a fancy word for how the receptors tend to be distributed. The cannabinoids get metabolized, in rates that are usually at how fast they degrade. The truth is, everyone’s ECS is very different, so you may respond to the differences in THC in some cases at a much larger level.
You’re Anxiety-Prone
At low levels, THC tends to quell anxiety, but at higher levels, this can make you feel anxious and panicky in some cases. The CB1 receptor is the one responsible for it, and it’s been discovered that if these receptors are blocked, or if the gene that does encode these is not there, it causes greater anxiety. Those who have this tend to, even at low dosages, feel anxiety in the CB1 receptors, and this may help with unblocking them in some cases. But too much can cause more stress and anxiety at work, so if you are someone who tends to be anxious, keep this in mind.
Dietary changes
Some people also have these issues if you’re taking certain foods in some cases. Here are some plants that have cannabinoids within this. If you reduce how many veggies and fruits have it may cause a difference in the way you respond to this.
But remember there is no evidence that supports this, so take this more as supposition rather than juts a fact. However, alcohol does impact the effects of THC. If you did use alcohol right beforehand, and its not out of the body, it does make you a bit more sensitive to this.
Also, certain opioids, stimulants and sedatives can actually be impacted too. Opioids and benzos do impact the response of THC, even in tiny doses. If you plan to take cannabis, and you’ve made some changes or consumed alcohol beforehand, keep this in mind, as it can be a major part of why you respond. These are the main reasons why you may respond differently when you intake THC, and why your tolerance is low.
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